The site stands on a small convent and a hospice built by the monks of San Girolamo around the middle of the fourteenth century; next to it was also founded the oratory dedicated to Santa Maria Assunta which was shortly after transformed into a church dedicated to San Sebastiano (protector of the plague victims) by the population who lived nearby and who survived the plague.
The current building was erected towards the middle of the sixteenth century on a project, it seems, by Antonio Abbondi, known as Lo Scarpagnino, who changed the orientation of the plant.
This place of worship is a typical example of a Renaissance style church with a single nave and a square presbytery ending in a semicircular apse; there is also an interesting choir.
The façade is divided into two parts horizontally by a high cornice and crowned by a triangular tympanum surmounted by statues; above, there is a circular rose window. Behind it, along Campo San Sebastian, is the quadrangular bell tower.
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