He was born in Capodistria on 29 March 1561 to Antonio, of Friulian origin, and Elisabetta Cordonia, from Capodistria. Antonio, the father, served the Serenissima as sopramassaro delle munizioni and at an early age Santorio moved to the lagoon city together with his brother Isidoro, while his sisters Piana and Franceschina remained in Capodistria where they married.In Venice he was able to study the humanities thanks to the support of the Morisini patricians, friends of the Sartorio family, and in 1575 he studied philosophy with Giacomo Zabarella and medicine with Bernardino Pat
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