The building - dedicated to the four virgins of Aquileia: Eufemia, Dorotea, Tecla and Erasma made martyrs by the Roman emperor Nero - represents the oldest building in Giudecca and one of the oldest in Venice.
It seems to have been built, for the first time, in 865 and - among the various adjustments - it was rebuilt in 1100. In 1380, the remains of the martyrs, previously deposited in Grado for 400 years, were placed under the main altar.
In addition to this restructuring, the church underwent other modifications in the seventeenth and eighteenth centuries, and t
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