Located in the westernmost point of the Grand Canal just before the Scalzi church, slightly set back to make room for a huge square, it is connected to the bus station (Piazzale Roma) through the recent Constitution bridge.
The building was built around 1860 - 1861 above the convent and church of Santa Lucia (from which the station took its name) and was then completely renovated in the first half of the twentieth century by engineer Paolo Perillico with the help of the Office State Railways technician.
At the foot of the steps leading to the trains, on the left, there is a small fountain with a bronze statue of the Immaculate Conception made by Francesco Scarpa Bolla in memory of the destroyed church of Santa Lucia.
